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2020


   M. G. Beaver,* E. Zhang, * Z. LiuS. ZhengB. WangJ. LuJ. TaoM. Gonzalez, S. Jones, J. S. Tedrow, Development and Execution of a Production-Scale Continuous [2+2] Photocycloaddition, Org. Process Res. Dev. 2020, ASAP.


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 P. Garcia-Losada,* A. C. DeBaillie, J. E. Diego, S. J. Green, M. M. Hansen, C. Jaramillo, M. Johnson, T. Kaoudi, J. Li, P. J. Lindsay-Scott, C. Mateos, D.J. Mergott, J. A. Rincon, R.R. Rothhaar, K. D. Seibert, B. M. Watson, L. L. Winneroski, S. GangulaD. JingH. SunL. Zhang, and M. O. Frederick,* Synthesis, Optimization, and Large-Scale Preparation of the LowDose Central Nervous System-Penetrant BACE1 Inhibitor LY3202626 via a [3 + 2] Nitrone Cycloaddition, Org. Process Res. Dev. 202024, 306−314.


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2019


Borovika, Alina; Albrecht, Jacob; Li, Jun; Wells, Andrew S.; Briddell, Christiana; Dillon, Barry R.; Diorazio, Louis J.; Gage, James R.; Gallou, Fabrice; Koenig, Stefan G.; et al. The PMI Predictor app to enable green-by-design chemical synthesis. Nat Sustain 2, 1034–1040 (2019).

  

V. S. Chan, S. W. Krabbe,C. LiL. SunY. Liu, A. J. Nett, Identification of an Oxalamide Ligand for Copper-Catalyzed C–O Couplings from a Pharmaceutical Compound Library,ChemCatChem 2019, 11, 5748-5753. .


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  Y. Takahira, M. Chen, Y. Kawamata, P. Mykhailiuk, H. Nakamura, B. K. Peters, S. H. Reisberg, C. Li, L. Chen, T. Hoshikawa, T. Shibuguchi, P. S. Baran, Electrochemical C(sp3)–H Fluorination, Synlett, 201930,1178-1182.


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 Y. Kawamata, J. C. Vantourout, D. P. Hickey, P. Bai,L. ChenQ. HouW. Qiao, K. Barman, M. A. Edwards, A. F. G.-C., J. N. deGruyter, H. Nakamura, K.W. Knouse, C. Qin, K. J. Clay, D. Bao, C. Li, J. T. Starr, C. G. Irizarry, N. Sach, H. S. White, M. Neurock, S. D. M., P. S. Baran, Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications, J. Am. Chem. Soc.2019141,6392-6402.


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  B. K. Peters, K. X. Rodriguez, S. H. Reisberg, S. B. Beil, D. P. Hickey, Y. Kawamata, M. Collins, J. Starr, L. Chen, S. Udyavara, K. Klunder, T. J. Gorey, S. L. Anderson, M. Neurock, S. D. Minteer, P. S. Baran, Scalable and safe synthetic organic electroreduction inspired by Li-ion battery chemistry, Science2019, 363, 838-845.


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2018


 J. Wang, H. Lundberga, S. Asaia, P. Martín-Acostaa, J. S. Chena, S. Brownb, W. Farrellc, R.G. Dushin, C. J. O’Donnell, A. S. Ratnayakeb, P.  Richardsonc, Z. Liu, T. Qin, D. G. Blackmond, P. S. Barana, Kinetically guided radical-based synthesis of C(sp3)−C(sp3) linkages on DNA,Proc. Natl. Acad. Sci.2018115, E6404-E6410.锚点锚点


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R.R. Merchant, J. T. Edwards, T. Qin, M. M. Kruszyk, C. Bi,G. Che, D. Bao, W. Qiao L. Sun, M. R. Collins, O. O. Fadeyi, G. M. Gallego, J. J. Mousseau, P. Nuhant, P. S. Baran, Modular radical cross-coupling with sulfones enables access to sp3-rich (fluoro)alkylated scaffolds,Science2018360,75-80.


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This is one of more than 60 examples of radical cross-couplings using new sulfone reagents with unique reactivity.



D. E. Hill, Q. PeiE. ZhangJ. R. Gage, J. Yu, D. G. Blackmond, A General Protocol for Addressing Speciation of the Active Catalyst Applied to Ligand-Accelerated Enantioselective C(sp3)−H Bond Arylation, ACS Catal. 20188, 1528−1531.


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2017


J.N. deGruyter, L. R. Malins, L. Wimmer, K. J. Clay, J. Lopez-Ogalla, T. Qin, J. Cornella, Z. LiuG. CheD. Bao, J. M. Stevens, J. X. Qiao, M. P. Allen, M. A. Poss, P. S. Baran, CITU: A Peptide and Decarboxylative Coupling Reagent, Org. Lett. 201719, 6196-6199.

  


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 Q. Pei, G. Che, R. Zhu, J.He, J. Yu,  An Epoxide-Mediated Deprotection Method for Acidic Amide Auxiliary, Org. Lett. 2017, 19, 5860-5863.


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 C. Li, Y. Kawamata, H. Nakamura, J. C. Vantourout, Z. Liu, Q. Hou, D. Bao, J.T. Starr, J.Chen, M. Yan, P.S. Baran, Electrochemically Enabled, Ni-Catalyzed Amination, Angew. Chem. Int. Ed., 2017, 56, 13088-13093.



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 J. M. Smith, T. Qin, R. R. Merchant, J. T. Edwards, L. R. Malins, Z. Liu, G. Che, Z. Shen, S. A. Shaw, M. D. Eastgate, P. S. Baran*, Decarboxylative Alkynylation, Angew. Chem. Int. Ed., 2017, 56, 11906-11910.



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  E. Hansen*, C. LiS. Yang, D. Pedro, D. Weix*, Coupling of Challenging Heteroaryl Halides with Alkyl Halides via Nickel-Catalyzed Cross-Electrophile Coupling, J. Org, Chem.201782, 7085-7694.




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Y. Kawamata, M. Yan, Z. Liu,D. Bao, J. Chen, J. T. Starr, P. S. Baran*, Scalable, Electrochemical Oxidation of Unactivated C−H Bonds,J. Am. Chem. Soc.,2017, 139, 7448–7451.



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 J. T. Edwards, R. R. Merchant, K. S. McClymont, K. W. Knouse, T. Qin, L. R. Malins, B. Vokits, S. A. Shaw, D.Bao, F. Wei, T. Zhou, M. D. Eastgate, P. S. Baran*, Decarboxylative alkenylation, Nature, 2017, 545,213-218.



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2016


 E. Zhang*, J. Tang, S. Li, P. Wu, J. E. Moses, K. B. Sharpless*,Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates, Chem. Eur. J.201622, 5692 – 5697.

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E. J. Horn, B. R. Rose, Y. ChenJ. Tang, K. Chen, M. D. Eastgate, P. S. Baran*,  Scalable and sustainable electrochemical allylic C-H oxidation, Nature,2016533, 78-81.锚点锚点



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2012


 J. R. Gage,*X. Guo, J.Tao, C. Zheng, High Output Continuous Nitration, Org. Process Res. Dev. 2012, 16, 930−933.



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凯莱英医药集团
  • 地址:天津市经济技术开发区第七大街71号
  • 邮编:300457
  • 总机:022-66252888
  • 传真:022-66252777
国内业务
  • 邮箱:BDchina@asymchem.com.cn
  • 负责接收国内客户,技术咨询,相关邮件
证券事务
  • 邮箱:securities@asymchem.com.cn
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